Temporal Association Rule Mining in China’s Closed-end Fund Data

Financial market plays an important role in economy. Although funds developed only a few years in China, it has been a focal point in research and practice. The conventional methods analyzing fund data are fundamental analysis and technical analysis. Data mining can extract implicit, previously unknown and potentially useful knowledge from data. This paper presents the new technique to analyze China’s closed-end fund data and temporal association rules (TAR) are discovered which reflect the relationship among open price, close price, trading volume and grail index. Experimental results show some interesting outcomes

The crossing number of locally twisted cubes

The {\it crossing number} of a graph $G$ is the minimum number of pairwise intersections of edges in a drawing of $G$. Motivated by the recent work [Faria, L., Figueiredo, C.M.H. de, Sykora, O., Vrt'o, I.: An improved upper bound on the crossing number of the hypercube. J. Graph Theory {\bf 59}, 145--161 (2008)] which solves the upper bound conjecture on the crossing number of $n$-dimensional hypercube proposed by Erd\H{o}s and Guy, we give upper and lower bounds of the crossing number of locally twisted cube, which is one of variants of hypercube.Comment: 17 pages, 12 figure

Application Research and Practice of TBL Innovative Teaching Method in the Course of Clinical Biochemical Testing Technology

The purpose of this study is to explore the practical application effect of TBL innovative teaching method in the course of clinical biochemistry test technology. The research object is all undergraduate students in the laboratory major of 2018 medical school of our university. The research method is comparative experiment method, the teaching method of LBL teaching is set as control group, while the experimental group adopts TBL teaching method. By the final teaching evaluation and the data collected in the process, the influence of TBL teaching methods on the teaching effect of the course is compared and analyzed. The evaluation methods are combined with subjective and objective evaluation. The evaluation methods include questionnaire, student mutual evaluation, final test and other multiple ways. And the results of this study showed that the average score of the experimental group using TBL teaching method was significantly higher than that of the control group using traditional teaching method. In addition, through the process evaluation, it was found that the students in the experimental group were superior to the students in the control group in terms of learning interest, communication ability and learning methods. As a result, the application of TBL teaching method in the teaching of clinical biochemistry test obviously promotes the teaching quality and effect of this course

First-line treatment for chronic myeloid leukemia: dasatinib, nilotinib, or imatinib

Imatinib, a tyrosine kinase inhibitor (TKI) of BCR-ABL, was the standard first-line therapy for chronic myeloid leukemia (CML) for almost 10 years. Dasatinib and nilotinib, two newer drugs with higher potency than imatinib against BCR-ABL and activity against most imatinib-resistant BCR-ABL mutations, have each shown superior efficacy compared with imatinib for first-line treatment of chronic-phase CML in randomized phase 3 trials. With 14 months follow-up time, available data suggest no obvious differences in efficacy between dasatinib and nilotinib. Compared with imatinib, dasatinib is associated with higher rates of pleural effusion and thrombocytopenia, but lower rates of edema, gastrointestinal AEs, musculoskeletal AEs, and rash. Nilotinib is associated with higher rates of dermatologic toxicity, headache, and biochemical abnormalities associated with hepatic and pancreatic toxicity compared with imatinib, but lower rates of edema, gastrointestinal AEs, muscle spasm, and neutropenia. Several studies have shown that poor adherence to imatinib detrimentally affects responses and should be considered in patients with a suboptimal response. The different dosing requirements of dasatinib (once daily with or without food) and nilotinib (twice daily with fasting) may be an additional factor in selecting frontline agents. This review compares and contrasts the three FDA approved first line TKI agents